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Post Translational Modifications and Interactome of STAT3

thesis
posted on 01.09.2020, 00:44 authored by SELLAPPERUMAGE CHAMIRA DILANKA FERNANDO
Signal Transducer and Activator of Transcription (STAT)3 is a member of the STAT family of latent transcription factors that relays signals from the extracellular environment to the nucleus. Whilst the activity of STAT3 is crucial for a plethora of biological functions, its dysregulated activity is implicated in many human tumours. However, the STAT3 activation mechanism and its biological consequences are far more complex than first thought. This thesis contributes to the current knowledge of STAT3 biology by investigating its non-genomic activities, post-translational modifications that regulate STAT3 activity and provides strategies for obtaining stable and pure full-length protein for structural studies.

History

Principal supervisor

Daniel Gough

Additional supervisor 1

Daniel Garama

Year of Award

2020

Department, School or Centre

Molecular and Translational Sciences

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences