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Phytochemical and Biological Evaluation of Selected Medicinal Plants (from Pakistan)

thesis
posted on 22.02.2021, 03:55 by Hammad Saleem
This thesis investigated the phytochemical and pharmacological properties of four medicinal plants: Anagallis arvensis, Bougainvillea glabra, Buxus papillosa, and Filago germanica. Phytochemical screening was performed by total bioactive contents, UHPLC-MS, and HPLC analysis. Antioxidant potential was determined by DPPH, ABTS, CUPRAC, FRAP, TAC, and MCA assays. Inhibitory activities were tested against cholinesterases, α-glucosidase, α-amylase, urease, LOX, and tyrosinase enzymes. Anticancer activity was tested on MCF-7, MDA-MB-231, CaSki, DU-145, and SW-480 cell lines. The active extracts resulted in isolation of 5,7,3'-trihydroxy-6,4',5'-trimethoxyflavone, 5-hydroxy-3, 7-dimethoxy-2-(4'-methoxyphenyl)-flavone, 5,7-dihydroxy-2-(5’-hydroxy-3’, 4’-dimethoxyphenyl)-flavone, β-sitosterol, and 3-(2’-hydroxy-4’, 5’-dimethoxyphenyl)-8-methoxy-isoflavone. The studied plants can be considered as promising origin for natural compounds.

History

Campus location

Malaysia

Principal supervisor

Nafees Ahemad Yunus

Year of Award

2021

Department, School or Centre

School of Pharmacy (Malaysia)

Course

Doctor of Philosophy

Degree Type

DOCTORATE

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