Perturbation of cell-cell and cell-macromolecule interactions and their associated signalling cascades by biodegradable nanoparticle-assisted delivery of siRNA and study of consequential chemosensitization of breast cancer

Cell-cell and cell-extracellular matrix adhesion is important for proliferation and differentiation of cells. This adhesion is provided by cell adhesion molecules linking with each other and receptor molecules. However, in breast cancer, adherence is either over regulated or under regulated, triggering essential oncogenic pathways and promoting tumor. Thus, in order to control the invasiveness of tumor cells and reduce metastasis, regulating cell adhesion interaction by targeting critical adhesion molecules, single and/or in combination via siRNA/gene/drug therapy was done. We used carbonate apatite, an inorganic pH sensitive nanoparticles, as carrier vehicle to deliver complexes in breast cancer cells and in murine models.