L181 Berry_PhD_Thesis_2018b_Redacted.pdf (27.08 MB)
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Personalised medicine for pancreatic cancer: using endoscopic ultrasound-guided biopsy for the development of a personalised pre-clinical model of disease

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thesis
posted on 27.03.2019, 21:15 by WILLIAM ARCHER BERRY
While pancreatic cancer is a genetically heterogeneous disease, 90% of patients exhibit mutations in KRAS. Most patients also respond poorly to generalised treatments, suggesting that patient outcomes may depend on genetic profiling and personalised therapeutic approaches. A potential role for those approaches is explored here, using tumour tissue procured from patients via a minimally invasive sampling technique to test for KRAS mutation status and whether KRAS mutation influenced tumour response to treatment. Only KRAS wild-type tumours were sensitive to the drug. These techniques allow for rapid translational research, from biomarker discovery to clinical trials.

History

Principal supervisor

Brendan Jenkins

Additional supervisor 1

Daniel Croagh

Year of Award

2018

Department, School or Centre

Molecular and Translational Sciences

Additional Institution or Organisation

Hudson Institute of Medical Research; Monash Health

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences