6392321_24926310SBDThesisrevisedfinal.pdf (33.99 MB)

Peptide toxins: structure, stability and engineering

Download (33.99 MB)
thesis
posted on 30.05.2018, 15:25 by STEPHEN BERNARD DRANE
This thesis is an investigation of peptide toxins from animal venom, aimed to determine the utility of the scorpion toxin HsTX1, as well as the conotoxins H_Vc7.1, H_Vc7.2 and contryphan-Vc2. Part of the work includes efforts undertaken to validate the scorpion toxin HsTX1 from the species Heterometrus spinifer as a scaffold structure for peptide engineering by molecular grafting. In addition, the production and biochemical characterisation of recently discovered conotoxins found in the venom duct of the venomous marine snail Conus victoriae are described.

History

Campus location

Australia

Principal supervisor

Raymond Norton

Additional supervisor 1

Rodrigo Morales

Year of Award

2018

Department, School or Centre

Medicinal Chemistry

Additional Institution or Organisation

Monash Institute of Pharmaceutical Sciences

Course

Master of Pharmaceutical Science

Degree Type

MPHIL

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

Exports

Exports