Monash University

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Reason: Under embargo until August 2019. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Pathophysiological Effects of High Intraluminal Pressure in Cardiovascular Disease: A Role for Caveolin-1

posted on 2018-08-04, 00:30 authored by WALED ASSAM SHIHATA
Heart disease, the leading cause of death worldwide, is associated with a number of risk factors. However, hypertension, or high blood pressure, contributes to more deaths and disease globally than any other risk factor despite available treatments. Studies have looked at the biochemical events associated with hypertension, however none have looked at the role of pressure itself. This thesis examines the detrimental effects of pressure in the context of heart disease and shows for the first time the role of the caveolin-1 protein as a potential therapeutic target for hypertension-induced heart disease.


Principal supervisor

Andrew Murphy

Additional supervisor 1

Jaye Chin-Dusting

Year of Award


Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Baker Heart and Diabetes Institute

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences