Salberg PhD Thesis - Revised - Upload.pdf (5.36 MB)
Pain in the Developing Brain: Early Life Adversities that Affect the Development of Chronic Pain in Adolescence
thesis
posted on 2022-11-02, 08:02 authored by SABRINA ROSE SALBERGChronic pain is a public health epidemic with 20% of youth that undergo surgery or sustain a mild brain injury suffering from persisting pain. Chronic pain has limited effective treatment options and often arises from an unknown cause. However, I have demonstrated that early life adversities, such as adverse childhood experiences and high-fat high-sugar diets, can increase risk for chronic pain by increasing inflammation and immune activation, and that females exhibit greater pain responses than males. Interestingly, the underlying mechanisms driving the chronification of pain differed between males and females, necessitating further investigation into the sexual dimorphism of persistent pain.
History
Principal supervisor
RichelleAdditional supervisor 1
Glenn YamakawaAdditional supervisor 2
Rhys BradyYear of Award
2022Department, School or Centre
Central Clinical SchoolAdditional Institution or Organisation
NeuroscienceCampus location
AustraliaCourse
Doctor of PhilosophyDegree Type
DOCTORATEFaculty
Faculty of Medicine, Nursing and Health SciencesUsage metrics
Keywords
High-fat high-sugar dietDietAdverse childhood experienceACEChronic painPersistent painAcute painAdolescenceMicrogliaNeuroinflammationInflammationHPA axisEarly life stressEarly life adversitySurgeryMild traumatic brain injuryConcussionPost-surgical painPost-traumatic headacheMRISex differencesNociceptionGene expressionNeuroimagingGrey matter densityTelomereCytokineRodentBehaviour
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC