Pain-on-a-chip: towards a cell-based microfluidic biosensor for the detection of nociceptive response in complex biological fluids

The absence of quantitative pain detection tools and the lack of appropriate nociceptive cell models for drug development has significantly impacted the diagnosis and treatment of chronic pain. The research presented in this thesis focuses on the development and validation of a cell-based microfluidic biosensor for nociceptive detection. By combining neuroscience with microfluidic technology, a multidisciplinary approach was utilized.