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Reason: Under embargo until 8 July 2025. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
PERIPHERAL AND CENTRAL IMMUNE BIOMARKERS OF DRUG RESISTANT EPILEPSY AND STATUS EPILEPTICUS
thesis
posted on 2024-07-08, 09:38 authored by TRACIE HUEY-LIN TANEpilepsy is a devastating neurological condition with approximately 36% of individuals experiencing medication resistant seizures. Status epilepticus is a severe manifestation of seizures with high mortality. Better treatments are required to reduce seizure frequency and severity. This thesis examined the role of inflammation in medication resistant epilepsy and status epilepticus. A variety of alterations in immunological markers in peripheral blood and epilepsy patient derived brain specimens were identified. This work advances our understanding of possible cellular and molecular immunological mechanisms of seizures. The knowledge gained is hoped to improve epilepsy diagnosis and treatment options.
