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Orphan G Protein-Coupled Receptor (GPCR) mediated regulation of metabolic inflammation
thesisposted on 21.11.2018, 02:10 by DARREN MARK RIDDY
Over 400 million people worldwide are diagnosed with type 2 diabetes mellitus (T2DM). This disease occurs due to both genetic and lifestyle factors. Infiltration of immune cells into tissues produces chronic low-grade inflammation and plays a key role in the development and progression of the disease. Deletion of the orphan G protein-coupled receptor, GPR21, reduced the migration of isolated human and mouse monocytes and improved the insulin sensitivity of mice. Identification a selective GPR21 agonist allowed characterisation of the potential signalling mechanism involved. These findings provide support that GPR21 is a suitable drug target for the treatment of metabolic inflammation.