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Reason: Under embargo until May 2020. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Oncogenic dependency on STAT3 serine phosphorylation in Kras mutant lung cancer and cachexia
thesisposted on 2019-05-21, 02:36 authored by SULTAN MOHAMMED A ALHAYYANI
Lung adenocarcinoma (LAC) is the most common (~40%) form of lung cancer, LAC is strongly associated with chronic lung inflammation triggered by cigarette smoking, and one of the most established disease-associated consequences of the genotoxic effects of cigarette-derived carcinogens is activating mutations in the Kras proto-oncogene. STAT3 has been shown to promote tumourigenesis. Therefore, we hypothesise that serine phosphorylation of STAT3 is a key event in the molecular pathogenesis of Kras-induced LAC. We discovered that STAT3 serine phosphorylation is required for both nuclear and mitochondrial function of STAT3 in Kras-induced LAC.