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Oncogenic dependency on STAT3 serine phosphorylation in Kras mutant lung cancer and cachexia

thesis
posted on 21.05.2019, 02:36 by SULTAN MOHAMMED A ALHAYYANI
Lung adenocarcinoma (LAC) is the most common (~40%) form of lung cancer, LAC is strongly associated with chronic lung inflammation triggered by cigarette smoking, and one of the most established disease-associated consequences of the genotoxic effects of cigarette-derived carcinogens is activating mutations in the Kras proto-oncogene. STAT3 has been shown to promote tumourigenesis. Therefore, we hypothesise that serine phosphorylation of STAT3 is a key event in the molecular pathogenesis of Kras-induced LAC. We discovered that STAT3 serine phosphorylation is required for both nuclear and mitochondrial function of STAT3 in Kras-induced LAC.

History

Principal supervisor

Brendan Jenkins

Year of Award

2019

Department, School or Centre

Molecular and Translational Sciences

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

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