CHAKRABORTY Amlan-PhD Thesis-Final Version-July 2019-without signature.pdf (30.08 MB)

On the Development of Immunomodulators for Attenuation of Airway Inflammation

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thesis
posted on 15.07.2019, 23:34 by AMLAN CHAKRABORTY
The increasing level of pollution by the presence of particulates and bacteria leads to respiratory diseases such as asthma, characterised by inflammation and difficulty in breathing. Current treatments with corticosteroids and anti-inflammatories like statins are ineffective due to adverse effects such as increased blood pressure, chest pain and obesity to name a few. We demonstrated for the first time, the role of amino acid (glycine) as an anti-inflammatory agent, capable of reducing lung inflammation and improving lung function. The ultrafine glycine-coated particles can be encapsulated in larger glycine microspheres for delivery via dry powder inhaler for therapeutic use.

History

Campus location

Australia

Principal supervisor

Cordelia Selomulya

Additional supervisor 1

Magdalena Plebanski

Additional supervisor 2

Simon G. Royce

Additional supervisor 3

Jennifer C. Boer

Additional supervisor 4

Mark Wright

Year of Award

2019

Department, School or Centre

Chemical Engineering

Additional Institution or Organisation

Department of Immunology, Monash University, Melbourne, Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Engineering

Exports