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Novel radioligands of MERTK for PET imaging and phenotyping of multiple sclerosis diagnosis
thesisposted on 18.11.2020, 02:48 by SIU WAI WONG
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system. There is currently no cure for MS and its management is challenging in progressive MS. A protein target, MERTK, has been reported to be upregulated with microglia level, which indicates the reparative process in MS. This thesis identifies MERTK-specific compounds that can be used as imaging agents of the brain, which allows for the stratification of MS patients based on disease states and hence for better therapeutic management.