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Novel models to assess drug absorption from lipid-based formulations

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thesis
posted on 28.05.2019, 13:38 by ESTELLE SUYS
Drug candidates with low aqueous solubility and low permeability are increasingly common in modern drug discovery programs. These properties, however, are problematic for the oral administration of these drugs as the intestinal absorption and uptake in blood will be hampered. Dissolving these drugs in lipid-based formulations (LBFs) can overcome the solubility barrier and polymers may be added to increase drug absorption. Little is known about the driving forces of absorption from these LBFs in the presence of polymers. This thesis describes the development of in vitro, in vivo, and computational models to understand this process.

History

Campus location

Australia

Principal supervisor

Colin Pouton

Additional supervisor 1

Christopher Porter

Additional supervisor 2

David Chalmers

Year of Award

2019

Department, School or Centre

Drug Delivery, Disposition and Dynamics

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences