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Novel engineering methods for the development of optogenetic tools

thesis
posted on 05.11.2021, 01:10 authored by ALEXANDRA-MADELAINE TICHY
This thesis addresses two major challenges in the field of cellular optogenetics. It provides a streamlined method and plasmid repository for the engineering of light-activated protein-protein interactions, and introduces a conceptually novel design approach for light-activated G-protein coupled receptors based on structural information. This work facilitates the broader accessibility of optogenetics and presents significant improvements in activity and applicability of current optogenetic tools.

History

Principal supervisor

Harald Janovjak

Year of Award

2021

Department, School or Centre

Australian Regenerative Medicine Institute (ARMI)

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences