Monash University

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Novel Targets of the JAK-STAT Signalling Pathway in Myeloproliferative Neoplasms

posted on 2023-02-23, 02:39 authored by CHARLENE LAM
The JAK2V617F mutation triggers constitutive activation of the JAK2 signalling pathway via STAT3 and STAT5 to drive expression of genes that govern disease phenotypes in myeloproliferative neoplasms (MPNs). The current JAK2 inhibitors (JAK2i) are effective in alleviating symptoms but do not reduce the JAK2 mutant allele burden and may lead to re-activation of compensatory resistance mechanisms. This thesis sought to identify novel targets by deciphering the transcriptional regulation of the central JAK-STAT signalling pathway in human erythroid and JAK2V617F-positive MPN cell models. The findings will aid in the identification of better biomarkers and targeted therapies for MPNs.


Principal supervisor

Andrew Perkins

Additional supervisor 1

Kevin Gillinder

Year of Award


Department, School or Centre

Central Clinical School

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences