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Novel Agents Targeting Sphingolipid Signalling

thesis
posted on 19.05.2018 by CARMEN VITTORIA SCULLINO
This thesis explores the sphingolipid pathway as a novel area of therapy in the treatment of cancer, fibrosis and multiple sclerosis. In a scaffold-hopping approach we have developed a compound library of drug-like non-lipid sphingolipid mimetics with improved phenotypic, physicochemical and pharmacokinetic activity relative to current frontrunners, as part of an ongoing optimisation effort. Our compounds further demonstrate a unique mechanism of action, which overcomes pathway redundancy of contemporary kinase inhibitors and receptor antagonists through phosphatase activation. As well as focusing on the development of viable drug candidates, this work further investigates the structure-activity relationship of our compounds in connection to activity.

History

Principal supervisor

Bernard Flynn

Year of Award

2018

Department, School or Centre

Medicinal Chemistry

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

Exports