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New polymeric nanoparticles to interrupt the ROS- and RNS- derived misregulation of cells

thesis
posted on 03.05.2021, 07:11 by VAN NAM DAO
The aim of this thesis is to use advanced polymer design to develop new biomaterials that can intercept biochemical signalling pathways. The developed materials react either directly or indirectly with reactive oxygen species and/or reactive nitrogen species, and confer downstream effects in the biological milieu. Four main categories of materials were developed: trisulfide-bearing polymers for releasing hydrogen sulfide and persulfides, polymer carriers for intracellular delivery of N-acetyl L-cysteine, star polymers for conjugating a small molecule antioxidant (TEMPO) and nitric oxide-scavenging polymers. The macromolecules were well-characterised and exhibited the desired biological activity. Such materials have potential application in pharmaceutics and oncology.

History

Campus location

Australia

Principal supervisor

John F Quinn

Additional supervisor 1

Michael Whittaker

Additional supervisor 2

Erica Sloan

Year of Award

2021

Department, School or Centre

Drug Delivery, Disposition and Dynamics

Additional Institution or Organisation

Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

Exports