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New malaria vaccines based on merozoite surface protein 2

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thesis
posted on 30.07.2018 by JEFFREY TIEN-JIE SEOW
The work in this thesis details the design of new malaria vaccine candidates based on blood-stage antigen merozoite surface protein 2 (MSP2). Structural biology and vaccine design were combined in the emerging field of structural vaccinology and applied to the intrinsically disordered protein. Using crystal structures of antibody-bound epitopes, novel peptide immunogens were designed for animal immunisations. The results of this work provide a promising platform for further development of broadly protective MSP2-based malaria vaccine candidates and may expand our understanding of the immune response towards other disordered antigens.

History

Campus location

Australia

Principal supervisor

Raymond Stanley Norton

Additional supervisor 1

Christopher A. MacRaild

Year of Award

2018

Department, School or Centre

Medicinal Chemistry

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

Exports

Exports