File(s) under permanent embargo
Reason: Restricted by author. A copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library, or by emailing firstname.lastname@example.org
New Approaches to the Synthesis of Pyrrolidines from 2-Azaallyl Anions and Azomethine Ylides
thesisposted on 09.10.2019, 04:31 by SHVETA PANDIANCHERRI
Pyrrolidines are ubiquitous chemical compounds. They are five-membered cyclic amines, found in many natural products, pharmaceuticals and catalysts. The synthesis of pyrrolidines and especially their enantioselective synthesis, is an important and long-standing challenge in organic chemistry. The research undertaken during the course of this PhD sought to explore new approaches for their formation. Consequently, this thesis has successfully detailed novel methods of accessing two distinctive reactive intermediates that were transformed into the required pyrrolidines and other functionalised amines. In addition, a modestly enantioselective reaction was also discovered, that is viable for future optimisation.