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Reason: Under embargo until 20 December 2024. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

NOVEL THERAPEUTIC STRATEGIES IN HEAD AND NECK SQUAMOUS CELL CARCINOMA

thesis
posted on 2023-12-19, 21:51 authored by Dijina Swaroop
We have previously described a novel proto-oncogenic axis (GRHL3/GSK3B/MYC) that is activated in many cases of human head and neck squamous cell carcinoma (HNSCC). In this thesis, we explore targeted therapy against this pathway using a bromodomain inhibitor (I-BET 151) in cellular and animal models. We have also expanded the repertoire of pre-clinical models of HNSCC that can be used for drug testing with development of a new protocol for organoid derivation. Cumulatively, the findings in this work may guide the development of novel therapeutic strategies in these poor prognosis cancers.

History

Principal supervisor

Smitha Rose

Additional supervisor 1

Stephen M Jane

Year of Award

2023

Department, School or Centre

Medicine - Alfred

Additional Institution or Organisation

Central Clinical School, Monash University

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

    Categories

    Keywords

    Head and neck cancerOral cancerOrganoidTargeted therapyPrecision medicineBromodomain inhibitorCancet therapyEpigenetic regulation of cancer

    Licence

    In Copyright

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