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NON-CLASSICAL RAS THERAPEUTIC TARGETS FOR HYPERTENSIVE CARDIO-RENAL FIBROSIS

thesis
posted on 22.02.2019, 01:33 by DHANIEL DIAS BARALDI
Cardiovascular disease is the leading cause of death in the world. There is often high blood pressure-related end-organ damage causing stiffening of the heart and kidneys. This thesis has examined the ability of a number of new drugs to reverse organ stiffening and has found that stimulation of a non-classical angiotensin site reversed fibrosis in adult, but not aged, hypertensive rats due to excessive collagen build-up. Importantly, combination therapy did not impair renal function in aged hypertensive rats. Therefore, adverse renal effects are not likely to be a limiting factor in the translation of these newer angiotensin-related compounds to the clinic.

History

Principal supervisor

Robert Edward Widdop

Year of Award

2019

Department, School or Centre

Pharmacology

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

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