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Reason: Under embargo until 6 March 2027. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

NK Cell Mediated Recognition and Killing of HIV-Infected Macrophages

thesis
posted on 2024-03-05, 21:59 authored by HANS KEK
HIV can infect a type of immune cell called macrophages, which persists in people with HIV despite anti-HIV therapy. These cells are a barrier to HIV cure, however, not much is known about how we can eliminate them. This thesis identified anti-HIV antibodies that can target HIV-infected macrophages and developed a modified anti-HIV antibody that can enhance immune killing of them. It also identified types of immune cells called natural killer cells that can effectively target HIV-infected macrophages. These natural killer cells may be used together with anti-HIV antibodies as part of an HIV cure immunotherapy in the future for people living with HIV.

History

Principal supervisor

Anna Hearps

Additional supervisor 1

Anthony Jaworowski

Additional supervisor 2

Bruce Wines

Year of Award

2024

Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Burnet Institute

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

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