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NAD+ regulation of mitochondrial calcium in C. elegans
thesisposted on 2023-03-17, 04:41 authored by Zexiong Su
Mitochondrial calcium plays a critical role in cellular energy production. The molecular machineries that control mitochondrial calcium transient have been identified. However, the metabolic regulation of mitochondrial calcium is less understood. In this thesis, I used C. elegans as a model organism and found cytosolic NAD+ was a regulatory mechanism for mitochondrial calcium homeostasis. NAD+ augmentation decreased mitochondrial calcium. In addition, mitochondrial calcium feedback modulated NAD+ content. Such mechanism generated a feedback circuit that contributed to both mitochondrial calcium and bioenergetics homeostasis, which was important for cellular energy homeostasis and cell health.