File(s) under embargo

3

month(s)

25

day(s)

until file(s) become available

NAD+ regulation of mitochondrial calcium in C. elegans

thesis
posted on 2023-03-17, 04:41 authored by Zexiong Su

Mitochondrial calcium plays a critical role in cellular energy production. The molecular machineries that control mitochondrial calcium transient have been identified. However, the metabolic regulation of mitochondrial calcium is less understood. In this thesis, I used C. elegans as a model organism and found cytosolic NAD+ was a regulatory mechanism for mitochondrial calcium homeostasis. NAD+ augmentation decreased mitochondrial calcium. In addition, mitochondrial calcium feedback modulated NAD+ content. Such mechanism generated a feedback circuit that contributed to both mitochondrial calcium and bioenergetics homeostasis, which was important for cellular energy homeostasis and cell health.

History

Principal supervisor

Jie Liu

Additional supervisor 1

Zhi-Cheng Xiao

Year of Award

2022

Department, School or Centre

Anatomy and Developmental Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences