File(s) under permanent embargo

Reason: Under embargo until August 2018. After this date a copy can be supplied under Section 51 (2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library or by emailing document.delivery@monash.edu

Myeloid cells in the regenerating salamander limb

thesis
posted on 06.08.2017, 23:33 by RYAN JOHN DEBUQUE
Salamanders exhibit remarkable capacities for tissue repair. The most famous example is the regenerating limb which is dependent on immune cells to control inflammation after amputation. This thesis provides approaches to study salamander immune cells and maps their origin and movements in the body before and after limb resection. In addition, it explores the evolutionary conservation of a molecular pathway that regulates inflammation during infection and injury. Together, these developments provide potential to deepen our understanding on how the salamander’s immune system contributes in a positive manner to tissue growth which can eventually be translated to clinical models in mammals.

History

Principal supervisor

Nadia Rosenthal

Additional supervisor 1

James Godwin

Year of Award

2017

Department, School or Centre

Australian Regenerative Medicine Institute (ARMI)

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

Doctorate

Faculty

Faculty of Medicine Nursing and Health Sciences