Myeloid cells in the regenerating salamander limb

Salamanders exhibit remarkable capacities for tissue repair. The most famous example is the regenerating limb which is dependent on immune cells to control inflammation after amputation. This thesis provides approaches to study salamander immune cells and maps their origin and movements in the body before and after limb resection. In addition, it explores the evolutionary conservation of a molecular pathway that regulates inflammation during infection and injury. Together, these developments provide potential to deepen our understanding on how the salamander’s immune system contributes in a positive manner to tissue growth which can eventually be translated to clinical models in mammals.