Monash University
5383117_Anitha Kopinathan_FINAL PhD_01092017.pdf (6.05 MB)

Multivalent Ligands as Chemical Probes for the Investigation of Dopamine D2 Receptor Pharmacology

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posted on 2017-09-10, 23:44 authored by ANITHA KOPINATHAN
The dopamine D2 receptor is a well-established therapeutic target for the treatment of central nervous system disorders such as schizophrenia and Parkinson’s disease. Although a number of treatments have been developed to target this receptor, our understanding of the structural and pharmacological aspects of the dopamine D2 receptor are still in its infancy. This thesis describes the design, synthesis and biological evaluation of chemical probes to investigate the structure and pharmacology of the dopamine D2 receptor. Through this work, it is envisaged that these probes will aid the development of novel treatments for central nervous system disorders with reduced side-effects.


Campus location


Principal supervisor

Ben Capuano

Additional supervisor 1

Peter Scammells

Additional supervisor 2

Jonathan Robert Lane

Year of Award


Department, School or Centre

Medicinal Chemistry

Additional Institution or Organisation

Monash Institute of Pharmaceutical Sciences


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences