Multiphysics numerical modelling for HIFU-induced bioeffects and controlled delivery of ablation dosage for oncological applications

Selective destruction of cancerous cells using ablative modalities like ultrasound relies on achieving a pre-defined threshold temperature level of the targeted region. The present work focuses on multiphysics modelling of thermal response of biological phantoms subjected to high intensity focused ultrasound (HIFU) with emphasis on real time monitoring of temperature of the heat-affected zone (lesion) and to control the size of the lesion. It is expected that this study will aid in destruction of cancerous cells in a calculated and controlled manner with minimum thermal damage to the intervening tissue and would provide thermal dosage guidance in HIFU-based treatment planning.