Multiomics dissection of Chikungunya virus pathogenesis reveals Neuropilin 2 as a novel therapeutic target

ADNAN, NUR AMELIA AZREEN

doi:10.26180/22777247.v1

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Multiomics dissection of Chikungunya virus pathogenesis reveals Neuropilin 2 as a novel therapeutic target

thesis

posted on 2023-05-08, 02:39 authored by NUR AMELIA AZREEN ADNAN

Chikungunya virus (CHIKV) can infect humans via Aedes mosquito bites and causes joint pain, fever, rashes and sometimes death in immunocompromised patients. Currently, there are no approved antivirals or vaccines for CHIKV. This thesis covers the pathogenesis of CHIKV in human muscle cells as well as the road to unveil the therapeutics target that can be used to reduce the CHIKV infection severity.

History

Principal supervisor

Vinod Balasubramaniam

Additional supervisor 1

Ammu Kutty Radakrishnan

Additional supervisor 2

Amreeta Dhanoa

Additional supervisor 3

Tham Hong Wai

Year of Award

2023

Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Campus location

Malaysia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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Keywords

Chikungunya virus Alphavirus Neuropilin 2 host-virus interaction antiviral yeast two-hybrid RNAseq

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Multiomics dissection of Chikungunya virus pathogenesis reveals Neuropilin 2 as a novel therapeutic target

History

Principal supervisor

Additional supervisor 1

Additional supervisor 2

Additional supervisor 3

Year of Award

Department, School or Centre

Campus location

Course

Degree Type

Faculty

Usage metrics

Categories

Keywords

Licence

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