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Reason: Under embargo until July 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Multifunctional branched poly(ester amide)s particles for brain targeting

thesis
posted on 2021-07-14, 13:08 authored by AADARASH ZIA
Brain diseases represent complex diseases due to lack of therapy which could be attributed to not fully know mechanisms and the presence of a barrier between blood and the brain that restricts the entry of therapeutic moieties. This thesis focuses on the development of brain-targeted particles which have the ability to cross the blood-brain barrier. It also highlights the development of physiologically relevant brain models and their use to study the behavior of these particles.

History

Campus location

Australia

Principal supervisor

Kristian Kempe

Additional supervisor 1

Thomas Paul Davis

Year of Award

2021

Department, School or Centre

Drug Delivery, Disposition and Dynamics

Additional Institution or Organisation

Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

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    Faculty of Pharmacy and Pharmaceutical Sciences Theses

    Categories

    Keywords

    BrainMicrofluidicsIn-vitro Blood-brain barrier modelNanoparticlesreceptor mediated transcytosisSZWIPN-acylated poly(amino ester)sPharmaceutical SciencesNeuroscienceNanomaterialsNanomedicine

    Licence

    In Copyright

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