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Multi-Omics Characterisation of Drug-Induced Liver Injury in Human-Derived Hepatocyte Models

thesis
posted on 30.10.2021, 07:04 by Thomas Petar Kralj
Drug-induced liver injury (DILI) is a significant clinical burden and is an issue for nearly all drug classes. The impact of DILI-associated drugs on the biochemistry of liver cells was characterised using advanced mass spectrometry approaches. This research revealed mechanisms and biomolecular changes associated with exposure to these drugs and offers new avenues to achieve a greater level of drug safety.

History

Campus location

Australia

Principal supervisor

Darren John Creek

Additional supervisor 1

Kim L.R. Brouwer

Year of Award

2021

Department, School or Centre

Drug Delivery, Disposition and Dynamics

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences