4719505_monash_172824.pdf (6.8 MB)
Download file

Molecular biology of host - influenza virus nucleoprotein (NP) interactions and their relevance in the pathogenesis of influenza virus.

Download (6.8 MB)
thesis
posted on 02.03.2017, 23:31 authored by Nailwal, Himani
Influenza A virus (IAV) proteins interact with an array of cellular proteins and hijack host pathways which are at the helm of cellular responses to facilitate virus invasion. This thesis identifies host protein, RING finger protein 43 (RNF43), a RING-type E3 ubiquitin ligase, as a novel interactor of nucleoprotein (NP) of IAV and an essential partner to induce NP-driven p53-mediated apoptosis and cell cycle arrest in IAV-infected cells. This thesis describes a novel strategy adopted by IAV for utilizing the much conserved ubiquitin proteasomal pathway and also unravels a promising host target for antiviral intervention.

History

Campus location

Australia

Principal supervisor

Sunil Kumar Lal

Additional supervisor 1

Ishwar Parhar

Additional supervisor 2

David James Young

Year of Award

2016

Department, School or Centre

School of Sciences (Monash University Malaysia)

Degree Type

DOCTORATE

Faculty

Faculty of Science