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Molecular and biochemical studies on Filamin A and its interaction with the nucleoprotein of Influenza A virus

thesis
posted on 04.09.2020, 04:00 authored by ANSHIKA SHARMA
The aim of this PhD thesis was to investigate the role of host Filamin A (FLNA) protein in the Influenza A virus (IAV) replication cycle. We found that FLNA plays a protective antiviral role in the host cell against the IAV. In addition, we also found that for successful IAV replication, the IAV nucleoprotein down-regulates FLNA levels as well as sequesters FLNA in order to activate the JNK stress signalling pathway, a pathway responsible for apoptosis induction and cell death.

History

Campus location

Malaysia

Principal supervisor

Sunil Kumar Lal

Additional supervisor 1

Kumaran Narayanan

Additional supervisor 2

Yap Khai Khun, Michelle

Year of Award

2020

Department, School or Centre

School of Sciences (Monash University Malaysia)

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Science