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Molecular and Cellular characterisation of novel viral CD8+ T cell epitopes from Influenza and SARS-CoV-2

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thesis
posted on 2022-12-04, 11:42 authored by ANDREA THUY NGUYEN
When a virus infects a cell, it gets broken down and small pieces of it called peptides are presented by antigen presenting molecules called Human Leukocyte Antigen (HLAs). HLAs present these viral peptides to T cells to flag that it has been infected for the T cells to destroy the infected cell. This thesis examines how T cells respond to different peptides derived from influenza and SARS-CoV-2 when presented by different HLA molecules.

History

Principal supervisor

Stephanie Gras

Additional supervisor 1

Emma Grant

Additional supervisor 2

Christopher Szeto

Year of Award

2022

Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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