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Reason: Under embargo until 17 October 2026. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Modulators of disease severity in multiple sclerosis

thesis
posted on 2023-10-17, 03:56 authored by MARIA PIA CAMPAGNA
Multiple sclerosis progresses differently in each person, and we don't fully understand why. Understanding this is crucial for personalised care, rather than a one-size-fits-all approach, and to find ways to stop the disease from worsening. In my PhD, I studied how genes modulate and predict disease severity. I observed that the central nervous system has a bigger role than the immune system in determining disease severity and showed that genes have small but potentially cumulative effects. I also identified specific genetic variations that could be helpful in predicting how well someone responds to treatment.

History

Principal supervisor

Vilija

Additional supervisor 1

Helmut Butzkueven

Additional supervisor 2

Jeannette Lechner-Scott

Additional supervisor 3

Rodney Lea

Year of Award

2023

Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Neuroscience

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences