Monash University

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Reason: Under embargo until 17 October 2026. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Modulators of disease severity in multiple sclerosis

posted on 2023-10-17, 03:56 authored by MARIA PIA CAMPAGNA
Multiple sclerosis progresses differently in each person, and we don't fully understand why. Understanding this is crucial for personalised care, rather than a one-size-fits-all approach, and to find ways to stop the disease from worsening. In my PhD, I studied how genes modulate and predict disease severity. I observed that the central nervous system has a bigger role than the immune system in determining disease severity and showed that genes have small but potentially cumulative effects. I also identified specific genetic variations that could be helpful in predicting how well someone responds to treatment.


Principal supervisor


Additional supervisor 1

Helmut Butzkueven

Additional supervisor 2

Jeannette Lechner-Scott

Additional supervisor 3

Rodney Lea

Year of Award


Department, School or Centre

Central Clinical School

Additional Institution or Organisation


Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences