Monash University

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Reason: Under embargo until May 2019. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Modulation of insulin resistance in conditions associated with high insulin resistance

posted on 2018-05-15, 00:05 authored by NEGAR NADERPOOR
Insulin resistance is a key factor in the development of diabetes. My thesis focuses on modulation of insulin resistance in obesity and polycystic ovary syndrome, two conditions characterised by insulin resistance. I explore the relationships between insulin resistance and kidney and liver function as well as faecal microbiota in overweight or obese individuals. I also show that vitamin D supplementation has no effect on insulin resistance in this population. Furthermore, I review the literature on the effect of obesity on polycystic ovary syndrome, the most common endocrine disease in reproductive-aged women. Finally, I compare the effect of combined lifestyle modification and metformin with lifestyle modification alone, on insulin resistance and other outcomes in polycystic ovary syndrome.


Principal supervisor

Barbora De Courten

Additional supervisor 1

Helena Teede

Year of Award


Department, School or Centre

Public Health and Preventive Medicine

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences