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Modulation of insulin resistance in conditions associated with high insulin resistance

thesis
posted on 15.05.2018, 00:05 by NEGAR NADERPOOR
Insulin resistance is a key factor in the development of diabetes. My thesis focuses on modulation of insulin resistance in obesity and polycystic ovary syndrome, two conditions characterised by insulin resistance. I explore the relationships between insulin resistance and kidney and liver function as well as faecal microbiota in overweight or obese individuals. I also show that vitamin D supplementation has no effect on insulin resistance in this population. Furthermore, I review the literature on the effect of obesity on polycystic ovary syndrome, the most common endocrine disease in reproductive-aged women. Finally, I compare the effect of combined lifestyle modification and metformin with lifestyle modification alone, on insulin resistance and other outcomes in polycystic ovary syndrome.

History

Principal supervisor

Barbora De Courten

Additional supervisor 1

Helena Teede

Year of Award

2018

Department, School or Centre

Public Health and Preventive Medicine

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

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