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Reason: Under embargo until December 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Modification and targetting of myeloid cell surface antigens (CD33 and CD123) to enhance the therapeutic index of CAR T-cells for acute myeloid leukaemia
thesis
posted on 2020-12-23, 04:49 authored by Katherine D CumminsAcute myeloid leukaemia is a blood cancer that affects adults and children, and has very poor therapeutic outcomes, even with the best available treatments including stem cell transplant. CAR T-cells are a novel gene therapy that have revolutionised treatment outcomes in other types of blood cancers. This thesis is dedicated to the development of CAR T-cells for the treatment of acute myeloid leukaemia, with the aim of improving remission rates and increasing the life expectancy of people who are diagnosed with this life-threatening blood cancer.
