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Modelling the interaction of influenza virus and its antibody

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thesis
posted on 2022-03-18, 00:34 authored by Shilian Xu
The influenza virus is a major human health concern. Pre-existing antibody-mediated immunity provide an irreplaceable role in the clearance of influenza virus via multiple mechanisms. Protection against influenza infection can be diminished by a diverse set of neutralisation escape mechanisms and by host exposure history. This study applied mathematical models to experimental data to explain how antibody concentration, viral inoculum size, and antisera-dependent enhancement determine influenza virus infectivity in the respiratory epithelium. This work proposed that antibody-induced bistable viral kinetics and antisera dependent enhancement was responsible for observed influenza A reinfection and vaccine-associated enhanced disease.

History

Principal supervisor

Celeste Donato

Additional supervisor 1

Ada Yan

Additional supervisor 2

Tonghua Zhang

Additional supervisor 3

Priscilla Johanesen

Year of Award

2022

Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Microbiology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences