YiZhangPhDThesisRevised6Oct2017.pdf (70.95 MB)

Modelling glioblastoma initiating cells and investigation of potential anti-cancer agents

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thesis
posted on 16.10.2017, 00:25 by YI ZHANG
Glioblastoma multiforme is the most common and malignant primary brain tumor within the Central Nervous System and can regrow after chemotherapy by way of glioblastoma initiating cells. This study focused on modeling glioblastoma initiating cells from mouse brain and investigated the difference in enzyme expression and phosphorylation levels between normal and glioblastoma initiating neural stem cells. In addition, 26 novel SANT-1 derivatives and 63 novel noscapine derivatives were investigated as potential anti-cancer agents.

History

Campus location

Australia

Principal supervisor

Colin Pouton

Year of Award

2017

Department, School or Centre

Drug Discovery Biology

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

Exports

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Exports