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Modelling and characterisation of mechanical behaviour of adherent cells in AFM indentation

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thesis
posted on 28.09.2020, 23:00 by TIANYAO SHEN
A single living biological cell is small in scale, but complex in structure. Various achievements have been fulfilled by microinjection process: injecting external particles at nanoscale into the living cells. This study investigates mechanical responses of biological cells being indented by atomic force microscope, from the cell’s deformation to the cell membrane disruption. The interactions between the living cell and the indenting probe are described by novelistically established models, and validated by experiments. The models established in this study illustrate the complex mechanical structure of the cell, furthering the understanding of the mechanical behaviour of the single cell during microinjection.

History

Campus location

Australia

Principal supervisor

Bijan Shirinzadeh

Additional supervisor 1

Damon Honnery

Year of Award

2020

Department, School or Centre

Mechanical and Aerospace Engineering

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Exports

Exports