PhDThesis_FirnaazAhamed_22Sep2020_2336_FINAL.pdf (10.13 MB)
Modelling Consolidated Bioprocessing of Cellulose via Population Balances Coupled with Cybernetic Models
thesis
posted on 2020-09-23, 08:32 authored by FIRNAAZ AHAMEDThe complexity of consolidated bioprocessing (CBP) for conversion of cellulosic biomass to biochemicals eludes a full mechanistic understanding of the underlying process fundamentals, thus, process and microbial strain optimizations are challenging. This research presents a new mechanistic modelling framework – Unified Cybernetic-Population Balance Model (UC-PBM) to address the limitations of CBP. Through the coupling of population balances and cybernetic models, this study reveals the necessity for a closed-loop control mechanism across multiple scales of process features to represent CBP at an adequate resolution to benefit rational reaction engineering. Insights from this work are crucial to overcome the limitations of cellulose bioprocessing.
History
Campus location
MalaysiaPrincipal supervisor
HoAdditional supervisor 1
Ooi Chien WeiYear of Award
2020Department, School or Centre
School of Engineering (Monash University Malaysia)Course
Doctor of PhilosophyDegree Type
DOCTORATEFaculty
Faculty of EngineeringUsage metrics
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Keywords
Consolidated bioprocessingCelluloseClostridium thermocellumMulti-layered population balance modelLumped hybrid cybernetic modelUnified cybernetic-population balance modelMetabolic pathway analysisBioprocessing, Bioproduction and BioproductsComputational BiologyBiological EngineeringSimulation and ModellingNumerical Solution of Differential and Integral EquationsNumerical Analysis
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