Lindblom_Thesis_Revised_4-2-20.pdf (10.75 MB)

Mitochondrial Function in Diabetic Kidney Disease: Insights from Targeting Mitochondrial Pore-forming Cell Death Proteins

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posted on 06.02.2020, 01:38 by RUNA SIGRID JOHANNA LINDBLOM
Diabetic kidney disease is one of the many complications that may develop in association with diabetes. Whilst lowering blood sugar and blood pressure can help prevent the loss of kidney function, additional therapies are still required. Previous studies have demonstrated that mitochondria become dysfunctional in the diabetic kidney, however, the present findings suggest that kidney mitochondria retain some capacity to adapt to the early challenges of diabetes. Further, by investigating the role of mitochondrial cell death proteins it was determined that a distinct approach will be required to improve kidney mitochondrial health in diabetes, due to their unique metabolic profile.

History

Principal supervisor

Melinda Coughlan

Additional supervisor 1

Mark Cooper

Additional supervisor 2

Gavin Higgins

Year of Award

2020

Department, School or Centre

Medicine - Alfred

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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