Monash University
FinalThesis_03032021.pdf (25.62 MB)
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Minimum Message Length Inference of Protein Alignments and Statistical Models of Amino Acid Evolution

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posted on 2021-03-04, 03:20 authored by DINITHI NAVODHYA SUMANAWEERA
Protein comparison via alignment is an indispensable first step for many biological studies. It forms a lynchpin to understand how proteins come about, function and evolve. The classical problem of protein sequence alignment is a broadly investigated topic, yet carries several limitations in the current state of the art. This thesis approaches the problem using the Bayesian criterion of Minimum Message Length that combines inductive inference with information theory and lossless data compression. It also develops a complete set of statistical models for sequence alignment, and at the end proposes a method to combine sequence with structure when searching for alignment relationships.


Campus location


Principal supervisor

Arun Konagurthu

Additional supervisor 1

Lloyd Allison

Year of Award


Department, School or Centre

Clayton School of Information Technology


Doctor of Philosophy

Degree Type



Faculty of Information Technology