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Microwave-assisted synthesis, characterisation, and evaluation of biological activities of pyridine-functionalised (benz)imidazolium salts

thesis
posted on 17.09.2021, 01:55 by WEE LI MAH
A series of novel bioactive chemical compounds were synthesised to combat drug resistance in both microorganisms and cancers. The compounds were synthesised in conventional laboratory settings, as well as with the use of microwave irradiation, to develop a more efficient synthesis methodology. In summary, a total of 20 compounds were synthesised and their antimicrobial and anticancer properties were evaluated. These compounds were found to be moderately active against the selected microorganism strains, while remarkably cytotoxic to the selected cancer cells. An improved methodology to synthesise the compounds using microwave irradiation was also established.

History

Campus location

Malaysia

Principal supervisor

Cheow Yuen Lin

Additional supervisor 1

Yeong Keng Yoon

Additional supervisor 2

Lee Sui Mae

Year of Award

2021

Department, School or Centre

School of Sciences (Monash University Malaysia)

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Science