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Metabolic engineering of yeast for production of cyclopropane fatty acids and growth on novel carbon feedstocks

thesis
posted on 28.02.2022, 22:16 by WEI JIANG
This thesis focuses on using two kinds of yeast Saccharomyces cerevisiae and Yarrowia lipolytica to produce a special fatty acid cyclopropane fatty acids. How this special fatty acid is synthesized in yeast was studied in this thesis. And based on the synthesis mechanism, an effective metabolic engineering strategy was applied to improve the yield of this special fatty acid. In addition, the yeast Yarrowia lipolytica was engineered to utilise a novel feedstock-methanol as a carbon source in this thesis.

History

Campus location

Australia

Principal supervisor

Victoria Haritos

Additional supervisor 1

Lizhong He

Additional supervisor 2

Rodrigo Ledesma Amaro

Year of Award

2022

Department, School or Centre

Chemical & Biological Engineering

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Engineering

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