Monash University

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Reason: Under embargo until 28 February 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library, or by emailing

Metabolic and musculoskeletal health in overweight and obese older adults

posted on 2022-02-16, 22:36 authored by Jakub Mesinovic
Metabolic disorders such as type 2 diabetes are increasing parallel to ageing and obesity and they have adverse effects on musculoskeletal health. This thesis demonstrated that poor metabolic health is associated with lower muscle and bone quality, concurrent exercise reduces bone loss due to diet-induced weight loss, and vitamin D supplementation enhances exercise-related improvements in body composition, in overweight and obese older adults. These findings suggest comprehensive musculoskeletal assessments are required in the clinical setting and exercise and dietary interventions are likely key for preventing and managing risk factors for falls and fractures in this growing population.


Principal supervisor

David Scott

Additional supervisor 1

Ayse Zengin

Additional supervisor 2

Barbora De Courten

Additional supervisor 3

Peter Ebeling

Year of Award


Department, School or Centre

Clinical Sciences at Monash Health

Additional Institution or Organisation


Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences