Monash University
Tim Fyfe - PhD Thesis - 25882511 - amended (mac no signatures).pdf (116.64 MB)
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Medicinal Chemistry & Chemical Biology Approaches to Investigate Prospective Treatments for CNS Diseases

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posted on 2019-08-22, 03:37 authored by TIMOTHY JOHN FYFE
Using techniques in Medicinal Chemistry and Chemical Biology, this thesis investigates novel prospective treatments for central nervous system disorders, namely schizophrenia and Parkinson’s disease. The dopamine receptors are heavily implicated in these diseases, and were the focus of this work. Small molecule allosteric modulators of these receptor systems interact with their receptor target in a unique way, and show promise as improved prospective treatments. As such, the identification of novel modulators that bind to this receptor system and the study of the way in which they influence chemical signalling was conducted through organic synthesis and molecular pharmacology studies.


Campus location


Principal supervisor

Ben Capuano

Additional supervisor 1

Professor Peter J. Scammells

Additional supervisor 2

Dr J. Robert Lane

Additional supervisor 3

Professor Barrie Kellam

Additional supervisor 4

Dr Shailesh Mistry

Year of Award


Department, School or Centre

Medicinal Chemistry

Additional Institution or Organisation

The University of Nottingham


Doctor of Philosophy (Joint Award and Doctoral Training Centre with The University of Nottingham)

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences