Raymond Shim PhD thesis final.pdf (8.27 MB)
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Mechanistic insights to infection after stroke for better targeted therapeutics

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thesis
posted on 25.08.2020, 04:37 by RAYMOND SHIM
Bacterial lung infection is a leading cause of death in patients with stroke. Use of antibiotics as both a therapy and prevention have failed, emphasising the requirement for new therapeutics to combat this fatal complication that plagues patients with stroke. This thesis explores changes to the immune system that leaves the body prone to developing infection following a stroke. These findings show that the degree of immune suppression is dictated by the severity of stroke and increases the risk of developing infection. With this knowledge, this thesis demonstrates that specifically activating certain immune cells can effectively combat post-stroke infection.

History

Principal supervisor

Connie Hoi Yee Wong

Additional supervisor 1

Shu Wen Wen

Additional supervisor 2

Christopher G. Sobey

Year of Award

2020

Department, School or Centre

Medicine - Monash Health

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

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