Mechanistic insights into biased agonism at the Glucagon-like peptide 1 receptor
thesisposted on 02.09.2020, 00:00 by Lachlan Clydesdale
Understanding how drugs for the Glucagon like peptide 1 receptor interact with their target can lead to the design of better therapeutics. This thesis uses techniques to study the way different drugs contacts the GLP-1 receptor and show this results intracellular signalling within the cell. This study identified unique patterns of interactions for different compounds targeting the receptor. This information can be used to design new drugs capable of interacting with the receptor and provides potential to maximise the therapeutic output, while minimising side effects.