Lachlan Clydesdale-23394935-Final Thesis.pdf (80.31 MB)
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Mechanistic insights into biased agonism at the Glucagon-like peptide 1 receptor

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posted on 02.09.2020, 00:00 by Lachlan Clydesdale
Understanding how drugs for the Glucagon like peptide 1 receptor interact with their target can lead to the design of better therapeutics. This thesis uses techniques to study the way different drugs contacts the GLP-1 receptor and show this results intracellular signalling within the cell. This study identified unique patterns of interactions for different compounds targeting the receptor. This information can be used to design new drugs capable of interacting with the receptor and provides potential to maximise the therapeutic output, while minimising side effects.


Campus location


Principal supervisor

Denise Laura Wootten

Additional supervisor 1

Patrick M. Sexton

Year of Award


Department, School or Centre

Drug Discovery Biology

Additional Institution or Organisation

Monash Institute of Pharmaceutical Sciences


Doctor of Philosophy

Degree Type


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